I am not estranged from my immediate family, but I am estranged from several members of my extended family (aunts, uncles, cousins), although that has nothing to do with my being gay, and frankly I don't miss them that much at all. Sometimes we're actually better off not being around certain people.
I've been cut off from several friends because of my sexuality, but never anyone in my immediate family. Luckily they've stood by me thick and thin.
If you're estranged from your immediate family, that's undoubtedly the hardest to deal with. I can only advise you to try to cultivate relationships with other relatives or close friends. You can't force other people to accept you, but remember that over time people can change their minds.
Continue to have a strong and solid prayer/spiritual life. Consider getting involved in a gay-friendly church and other social activities.
Sorry I can't offer more. Good luck!